HEMATOPOIESIS AND STEM CELLS FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation
نویسندگان
چکیده
Departments of 1Immunology and 2Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel; 3Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT; 4Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 5Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany; 6Center for Integrated Protein Science Munich and Institute of Organic Chemistry, University of Leipzig, Leipzig, Germany; and 7Institute for Cancer Research and Treatment, Laboratory of Clinical Oncology, University of Turin Medical School, Candiolo, Italy
منابع مشابه
FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.
Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not fully understood. In the present study, we show that whereas steady-state hematopoiesis is normal in basic fibroblast growth factor (FGF-2)-knockout mice, parathyroid hormone stimulation and myeloablative treatments failed to induce normal HSPC proliferation and recovery. In vivo FGF-2 treatment expanded stroma...
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Considerable information has accumulated about components of BM that regulate the survival, self-renewal, and differentiation of hematopoietic cells. In the present study, we investigated Wnt signaling and assessed its influence on human and murine hematopoiesis. Hematopoietic stem/progenitor cells (HSPCs) were placed on Wnt3a-transduced OP9 stromal cells. The proliferation and production of B ...
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